This presentation seeks to contribute to the debate on the position of the Society of Jesus in the face of the process of conquest and Christianization that the Spanish empire tried to implement in the southern regions of Chile, where the Mapuche Indians maintained secular military resistance and political autonomy. This position oscillated between, on the one hand, hope and enthusiasm at any sign from the indigenous people that pointed to what they understood – or wanted to understand – as an eventual acceptance of the Gospel and Christian rites; and, on the other hand, missionary frustration at the evidence that the indigenous “agency”, which had established itself in an autonomous and rebellious territory since the great revolt at the end of the 16th century destroyed the entire Spanish presence south of the Biobío river, it would end up being included in the behavior of a human universe described as “barbaric” and “savage”, incapable of being incorporated into Christian salvation… although it was possible to be baptized.